Mevasine

Mevasine - General Information

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mevasine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. [PubChem]

Pharmacology of Mevasine

Mevasine is a potent, oral antihypertensive agent and ganglion blocker, and is a secondary amine. Mevasine is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. Mevasine reduces blood pressure in both normotensive and hypertensive individuals. A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced. Mevasine crosses the blood-brain and placental barriers.

Mevasine for patients

Mevasine Interactions

Patients receiving antibiotics and sulfonamides generally should not be treated with ganglion blockers.

The action of Mecamylamine may be potentiated by anesthesia, other antihypertensive drugs and alcohol.

Mevasine Contraindications

Mecamylamine should not be used in mild, moderate, labile hypertension and may prove unsuitable in uncooperative patients. It is contraindicated in coronary insufficiency or recent myocardial infarction. Mecamylamine should be given with great discretion, if at all, when renal insufficiency is manifested by a rising or elevated BUN. The drug is contraindicated in uremia. Patients receiving antibiotics and sulfonamides should generally not be treated with ganglion blockers. Other contraindications are glaucoma, organic pyloric stenosis or hypersensitivity to the product.

Additional information about Mevasine

Mevasine Indication: For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension
Mechanism Of Action: Mevasine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mevasine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Mecamylamine
Synonyms: 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 3-Methylaminoisocamphane; 3-Methylaminoisocamphane hydrochloride; Mecamylamine Hydrochloride; Mecamilamina
Drug Category: Antihypertensive Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Mecamylamine: Inversine; Inversine hydrochloride; Mecamine; Mecamine hydrochloride; Mekamin hydrochloride; Mekamine; Mevasin hydrochloride; Mevasine; Revertina; Versamine;
Absorption: Mecamylamine is almost completely absorbed from the gastrointestinal tract
Toxicity (Overdose): Not Available
Protein Binding: 40%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Mevasine: Tablet Oral
Chemical IUPAC Name: N,5,6,6-tetramethylbicyclo[2.2.1]heptan-5-amine
Chemical Formula: C11H21N
Mecamylamine on Wikipedia: https://en.wikipedia.org/wiki/Mecamylamine
Organisms Affected: Humans and other mammals