Maxair
Maxair - General Information
Maxair is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established.
The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3†,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Pharmacology of Maxair
Maxair is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established.
Maxair for patients
IMPORTANT NOTE: Use MAXAIR AUTOHALER according to the instructions given to you by your physician, who will advise you on the number of inhalations to take. If you have previously been using MAXAIR Inhaler, you should take the same number of inhalations through your MAXAIR AUTOHALER as you did through the MAXAIR Inhaler. Before using your MAXAIR AUTOHALER, read complete instructions carefully. The light blue plastic actuator supplied with MAXAIR AUTOHALER should not be used with any other product canisters, and actuators from other products should not be used with a MAXAIR AUTOHALER canister.
The correct amount of medication in each canister cannot be assured after 80 actuations from the 2.8 g canister and 400 actuations from the 14.0 g canister, even though the canister is not completely empty. You should keep track ofthe number of actuations used from each MAXAIRAUTOHALER and discard the MAXAIR AUTOHALER after 80 actuations from the 2.8 g canister and 400 actuations from the 14.0 g canister. MAXAIR AUTOHALERshould be discarded when the labeled numbers of actuations have been used. Before you reach the specified number ofactuations, you should consult your physician to determine whether a refill is needed. Just as you should not take extra doses without consulting your physician, you also should not stop using MAXAIR AUTOHALER without consulting your physician.
Dosage: Use only as directed by your physician.
WARNINGS: The effects of MAXAIR AUTOHALER may last up to five hours or longer. Therefore, it should not be used more frequently than recommended. Do not increase the number or frequency of doses without speaking with the prescribing physician. If the recommended dosage does not provide relief of symptoms, or your symptoms get worse, speak with your physician. While taking MAXAIR AUTOHALER, other inhaled medicines should not be used unless prescribed.
Important Information: Store between 15° and 30° C (59° to 86° F). Failure to use this product within this temperature range may result in improper dosing. For optimal results, the canister should be at room temperature before use. Shake well before using.
Caution: Contents of canister under pressure. Do not puncture. Do not use near heat or open flame. Exposure to temperatures above 120° F may cause bursting. Never throw container into fire or incinerator. Avoid spraying in eyes. Keep out of reach of children.
Use MAXAIR AUTOHALER only as prescribed by your physician. Handle with care.
DO NOT USE WITH OTHER CANISTERS OR MOUTHPIECES.
For information on the drug, refer to your doctor or pharmacist.
Note: The indented statement below is required by the Federal Government's Clean Air Act for all products containing or manufactured with chloro-fluorocarbons (CFC' s).
This product contains trichloromono-fluoromethane and dichlorodifluoro-methane, substances which harm the environment by destroying ozone in the upper atmosphere.
Your physician has determined that this product is likely to help your personal health. USE THIS PRODUCT AS DIRECTED, UNLESS INSTRUCTED TO DO OTHERWISE BY YOUR PHYSICIAN. If you have any questions about alternatives, consult with your physician.
General Information about MAXAIR† AUTOHALER† (pirbuterol acetate inhalation aerosol)
Your MAXAIR AUTOHALER is a new type of inhaler designed to be very easy to use. MAXAIR AUTOHALER automatically releases an inhalation of medicine when you inhale.
What will I feel when I use MAXAIR AUTOHALER?
MAXAIR AUTOHALER provides a soft spray of medicine. It is designed to automatically deliver a precisely measured dose of your medicine with each inhalation, so you can be assured of a consistent dose of medicine. When medicine is delivered, you will hear a "click" and feel a soft inhalation.
How will I know when there's no more medicine in MAXAIR AUTOHALER?
The MAXAIR AUTOHALER you receive from the pharmacy contains 400 inhalations (the MAXAIR AUTOHALER sample contains 80 inhalations and says "SAMPLE" on the back; the MAXAIR AUTOHALER hospital unit also contains 80 inhalations and says "Hospital Pack" on the back). You can estimate how many days it will last by dividing 80 or 400 (total inhalations in a unit) by the number of inhalations you normally use in a day. The chart below can help you calculate about how long your 400 inhalation MAXAIR AUTOHALER will last. Actual usage may vary depending on how many inhalations you use each day. A total daily dose of 12 inhalations should not be exceeded.
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Maxair Interactions
Other short-acting beta adrenergic aerosol bronchodilators should not be used concomitantly with MAXAIR AUTOHALER because they may have additive effects.
Maxair Contraindications
MAXAIR AUTOHALER is contraindicated in patients with a history of hypersensitivity to pirbuterol or any of its ingredients.
Additional information about Maxair
Maxair Indication: For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible bronchospasm including asthma.
Mechanism Of Action: The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3&
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Pirbuterol
Synonyms: Pirbuterol hydrochloride; Pirbuterolum [inn-latin]
Drug Category: Adrenergic beta-Agonists; Bronchodilator Agents; Cardiotonic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Pirbuterol: Maxair;
Absorption: Not Available
Toxicity (Overdose): As with all sympathomimetic aerosol medication, cardiac arrest and even death may be associated with abuse of pirbuterol.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: The plasma half-life measured after oral administration is about two hours.
Dosage Forms of Maxair: Aerosol Respiratory (inhalation)
Chemical IUPAC Name: 6-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)pyridin-3-ol
Chemical Formula: C12H20N2O3
Pirbuterol on Wikipedia: Not Available
Organisms Affected: Humans and other mammals
