Mansil

Mansil - General Information

An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Mansil causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Extra Pharmacopoeia, 31st ed, p121)

Pharmacology of Mansil

Mansil is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Mansil causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release egg.

Additional information about Mansil

Mansil Indication: For treatment of Schistosomiasis caused by Schistosoma mansoni
Mechanism Of Action: Mansil may associates with an irreversible inhibition of the nucleic acid metabolism of the parasites. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome enzyme converts oxamniquine into an ester (probably acetate, phosphate, or sulfate). Subsequently, the ester spontaneously dissociates, the resulting electrophilic reactant is capable of alkylation of schistosome DNA.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Oxamniquine
Synonyms: Not Available
Drug Category: Schistosomicides
Drug Type: Small Molecule; Approved

Other Brand Names containing Oxamniquine: Mansil; Vansil;
Absorption: Well absorbed orally
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Probably hepatic
Half Life: 1-2.5 hours
Dosage Forms of Mansil: Not Available
Chemical IUPAC Name: [7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl]methanol
Chemical Formula: C14H21N3O3
Oxamniquine on Wikipedia: https://en.wikipedia.org/wiki/Oxamniquine
Organisms Affected: Schistosoma mansoni