Mansil: Full Drug Profile

Mansil - General Information

An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Mansil causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Extra Pharmacopoeia, 31st ed, p121)

Pharmacology of Mansil

Mansil is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Mansil causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release egg.

Additional information about Mansil

Mansil Indication: For treatment of Schistosomiasis caused by Schistosoma mansoni Mechanism Of Action: Mansil may associates with an irreversible inhibition of the nucleic acid metabolism of the parasites. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome enzyme converts oxamniquine into an ester (probably acetate, phosphate, or sulfate). Subsequently, the ester spontaneously dissociates, the resulting electrophilic reactant is capable of alkylation of schistosome DNA. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Oxamniquine Synonyms: Not Available Drug Category: Schistosomicides Drug Type: Small Molecule; Approved Other Brand Names containing Oxamniquine: Mansil; Vansil; Absorption: Well absorbed orally Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Probably hepatic Half Life: 1-2.5 hours Dosage Forms of Mansil: Not Available Chemical IUPAC Name: [7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl]methanol Chemical Formula: C14H21N3O3 Oxamniquine on Wikipedia: https://en.wikipedia.org/wiki/Oxamniquine Organisms Affected: Schistosoma mansoni