Manir
Manir - General Information
Manir is an anticholinergic drug (trade name Daricon) used in treating peptic ulcers.
Pharmacology of Manir
Manir is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Manir is an antimuscarinic, anticholinergic drug.
Additional information about Manir
Manir Indication: For the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders.
Mechanism Of Action: Manir binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Oxphencyclimine inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Oxyphencyclimine
Synonyms: Oxifencicliminum [Inn-Spanish]; Oxiphencycliminum; Oxyphencyclimine Hydrochloride; Oxyphencycliminum [Inn-Latin]
Drug Category: Anticholinergic Agents; Antispasmodics
Drug Type: Small Molecule; Approved
Other Brand Names containing Oxyphencyclimine: Antulcus; Caridan; Cycmin; Daricol; Daricon; Dominil; Enterex; Gastrix; Manir; Naridan; Oximin; Setrol; Spazamin; Syklifen; Ulcociclinina; Vio-Thene; W-T Anticholinergic; Zamanil;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Manir: Not Available
Chemical IUPAC Name: (1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
Chemical Formula: C20H28N2O3
Oxyphencyclimine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals
