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Manerix: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Manerix - General Information

A reversible inhibitor of monoamine oxidase type A; (RIMA); (see monoamine oxidase inhibitors) that has antidepressive properties. [PubChem]

 

Pharmacology of Manerix

Manerix belongs to a class of MAOI antidepressants known as reversible inhibitors of monoamine oxidase type-A (RIMAs). The primary role of monoamine oxidase MAO lies in the metabolism of and regulation of the levels of monoamines (serotonin, norepinephrine, and dopamine). Within neurons, MAO appears to regulate the levels of monoamines released upon synaptic firing. Since depression is associated with low levels of monoamines, the inhibition of MAO serves to ease depressive symptoms. RIMAs demonstrate transient inhibition of the substrate binding site of MAO-A as well as competitive displacement from this site by bioamines. The RIMAs are distinguished from the older monoamine oxidase inhibitors (MAOIs) by their selectivity and reversibility.

 

Additional information about Manerix

Manerix Indication

For the treatment of depression.

Mechanism Of Action
The mechanism of action of moclobemide involves the selective, reversible inhibition of MAO-A. This inhibition leads to a decrease in the metabolism and destruction of monoamines in the neurotransmitters. This results in an increase in the monoamines, relieving depressive symptoms.
Drug Interactions
Amitriptyline Possible severe adverse reaction with this combination
Generic Name
Moclobemide
Synonyms
Moclobemida [Inn-Spanish]; Moclobemide [Usan-Ban-Inn]; Moclobemidum [Inn-Latin]; 4-Chlor-N-(2-morpholinoethyl)benzamid; 4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide; 4-Chloro-N-(2-morpholin-4-yl-ethyl)-benzamide; Moclamine; Moclamide; Moclobemid; Moclaime; p-Chloro-N-(2-morpholinoethyl)benzamide
Drug Category
Antidepressive Agents; Monoamine Oxidase Inhibitors
Drug Type
Small Molecule; Approved; Investigational
Other Brand Names containing Moclobemide
Aurorix; Manerix;
Absorption
Well absorbed from the gastrointestinal tract. The presence of food reduces the rate but not the extent of absorption. Absolute bioavailability ranges from approximately 55% following administration of single doses of moclobemide to 90% following multiple dosing, due to the hepatic first pass effect.
Toxicity (Overdose)
LD50 (mouse) is 730mg/kg and LD50 (rat) is 1,300mg/kg
Protein Binding
Approximately 50% (primarily to albumin)
Biotransformation
Moclobemide is almost completely metabolized in the liver by Cytochrome P450 2C19 and 2D6.
Half Life
1.5 hours (4 hours in cirrhotic patients)
Dosage Forms of Manerix
Tablet Oral
Chemical IUPAC Name
4-chloro-N-(2-morpholin-4-ylethyl)benzamide
Chemical Formula
C13H17ClN2O2
Organisms Affected
Humans and other mammals