Lucassin

Lucassin - General Information

Lucassin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help. [Wikipedia]

Pharmacology of Lucassin

Lucassin is a medicine similar to a naturally occurring hormone present in the body, known as antidiuretic hormone (ADH) or vasopressin. ADH has two main effects in the body. Firstly, it causes narrowing of blood vessels (vasoconstriction), thereby limiting blood flow to a particular area of the body. It also acts on receptors in the kidney to retain water in the body, which helps to prevent excessive loss of water in the urine.

Additional information about Lucassin

Lucassin Indication: Commonly used to stop bleeding of varices in the food pipe (oesophagus).
Mechanism Of Action: Lucassin, an analogue of vasopressin, acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of terlipressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Terlipressin
Synonyms: Terlipressinum [INN-Latin]; Terlipressine [INN-French]; Terlipressina [INN-Spanish]; N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
Drug Category: Vasoconstrictor Agents; Antihypertensive Agents
Drug Type: Small Molecule; Approved; Investigational

Other Brand Names containing Terlipressin: Lucassin; Glypressin;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Approximately 30%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Lucassin: Injection, solution Intravenous
Chemical IUPAC Name: (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide
Chemical Formula: C52H74N16O15S2
Terlipressin on Wikipedia: https://en.wikipedia.org/wiki/Terlipressin
Organisms Affected: Humans and other mammals