Lopac-D-1260

Lopac-D-1260 - General Information

Lopac-D-1260 is a short acting depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. It is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor.

Pharmacology of Lopac-D-1260

Lopac-D-1260 acts as a depolarizing muscle relaxant or neuromuscular blocking agent. It acts as an agonist of nicotinic acetycholine receptors in the motor endplate and causes depolarization. This class of drugs has its effect at the neuromuscular junction by preventing the effects of acetylcholine. Normally, when a nerve stimulus acts to contract a muscle, it releases acetylcholine. The binding of this acetylcholine to receptors causes the muscle to contract. Muscle relaxants play an important role in anesthesia even though they don't provide any pain relief or produce unconsciousness.

Lopac-D-1260 for patients

Lopac-D-1260 Interactions

Potentially fatal drug interactions may occur when coadministered with digoxin, as this may enhance cardiovascular depression and bradyarrhythmias may occur. Anticholinesterases (neostgmine, physostigmine), lignocaine, quinine, procainamide can enhance toxicity and cause cardio respiratory depression. In addition, neuromuscular blocking action is enhanced by general anesthetics, local anesthetics like lidocaine, procaine, beta-blockers, metaclopramide, lithium carbonate, and terbutaline.

Lopac-D-1260 Contraindications

Additional information about Lopac-D-1260

Lopac-D-1260 Indication: For use as a skeletal muscle relaxant
Mechanism Of Action: Binds to the nicotinic acetycholine receptors (by virtue of its similarity to acetylcholine) in the motor endplate and blocks access to the receptors. In the process of binding, the receptor is actually activated - causing a process known as depolarization. Since it is not degraded in the neuromuscular junction, the depolarized membrance remains depolarized and unresponsive to any other impulse, causing muscle paralysis.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Decamethonium
Synonyms: Decamethonum
Drug Category: Neuromuscular Depolarizing Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Decamethonium: Syncurine; Lopac-D-1260;
Absorption: Rapidly absorbed.
Toxicity (Overdose): LD₅₀=190 mg/kg (orally in mice). Prolonged apnoea, neuromuscular paralysis and cardiac arrest may occur.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Lopac-D-1260: Not Available
Chemical IUPAC Name: trimethyl-(10-trimethylazaniumyldecyl)azanium
Chemical Formula: C16H38N2+2
Decamethonium on Wikipedia: https://en.wikipedia.org/wiki/Decamethonium
Organisms Affected: Humans and other mammals