Locorten

Locorten - General Information

Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

Pharmacology of Locorten

Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

Locorten for patients

Locorten Interactions

Locorten Contraindications

Known hypersensitivity to flumethasone pivalate or to corticosteroids in general. Animal studies have shown that corticosteroids may induce fetal abnormalities in pregnant animals. Contraindicated for tuberculosis of the skin, syphilitic skin infections, viral and acute fungal infections of the skin, rosacea, perioral dermatitis, acne vulgaris.

Additional information about Locorten

Locorten Indication: For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions
Mechanism Of Action: Flumethasone is a glucocorticoid receptor agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Flumethasone Pivalate
Synonyms: Not Available
Drug Category: Anti-inflammatory Agents; Glucocorticoids; Antipruritics
Drug Type: Small Molecule; Approved

Other Brand Names containing Flumethasone Pivalate: Locorten;
Absorption: Minimal if applied topically
Toxicity (Overdose): Can lead to signs of irritation such as burning sensation, itching or skin rash at the site of application; hypersensitivity reactions.
Protein Binding: Not Available
Biotransformation: Primarily hepatic
Half Life: Not Available
Dosage Forms of Locorten: Not Available
Chemical IUPAC Name: [2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate
Chemical Formula: C27H36F2O6
Flumethasone Pivalate on Wikipedia: Not Available
Organisms Affected: Humans and other mammals