Locorten: Full Drug Profile

Locorten - General Information

Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

Pharmacology of Locorten

Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

Locorten for patients

Locorten Interactions

Locorten Contraindications

Known hypersensitivity to flumethasone pivalate or to corticosteroids in general. Animal studies have shown that corticosteroids may induce fetal abnormalities in pregnant animals. Contraindicated for tuberculosis of the skin, syphilitic skin infections, viral and acute fungal infections of the skin, rosacea, perioral dermatitis, acne vulgaris.

Additional information about Locorten

Locorten Indication

For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions

Mechanism Of Action

Flumethasone is a glucocorticoid receptor agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.

Generic Name

Flumethasone Pivalate

Drug Category

Anti-inflammatory Agents; Glucocorticoids; Antipruritics

Drug Type

Small Molecule; Approved

Other Brand Names containing Flumethasone Pivalate

Locorten;

Absorption

Minimal if applied topically

Toxicity (Overdose)

Can lead to signs of irritation such as burning sensation, itching or skin rash at the site of application; hypersensitivity reactions.

Biotransformation

Primarily hepatic

Chemical IUPAC Name

[2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate

Chemical Formula

C27H36F2O6

Organisms Affected

Humans and other mammals