Lamasil
Lamasil - General Information
Lamasil hydrochloride (Lamisil) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene epoxidase, an enzyme that is part of the fungal cell wall synthesis pathway.
Pharmacology of Lamasil
Lamasil is an allylamine antifungal agent and acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. in vitro, mammalian squalene epoxidase is only inhibited at higher (4000 fold) concentrations than is needed for inhibition of the dermatophyte enzyme. Depending on the concentration of the drug and the fungal species test in vitro, Lamasil may be fungicidal. However, the clinical significance of in vitro data is unknown.
Lamasil for patients
Patient Information:
Discuss with you doctor about the risks of this medication before taking it.
Do not dring alcohol while you are taking Terbinafine, because liber problem may
occur. Contack you doctor if you experience any discomforts, for example, nausea, vomiting, loss of appetite,
yellow eys or skin.
Finsh the medication even if you feel better.
Lamasil Interactions
In vitro studies with human liver microsomes showed that terbinafine does not inhibit the metabolism of tolbutamide, ethinylestradiol, ethoxycoumarin, and cyclosporine. In vitro studies have also shown that terbinafine inhibits CYP2D6-mediated metabolism. This may be of clinical relevance for compounds predominantly metabolized by this enzyme, such as tricyclic antidepressants, ß-blockers, selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors (MAO-Is) Type B, if they have a narrow therapeutic window.
In vivo drug-drug interaction studies conducted in normal volunteer subjects showed that terbinafine does not affect the clearance of antipyrine or digoxin. Terbinafine decreases the clearance of caffeine by 19%. Terbinafine increases the clearance of cyclosporine by 15%.
There have been spontaneous reports of increase or decrease in prothrombin times in patients concomitantly taking oral terbinafine and warfarin, however, a causal relationship between LAMISIL Tablets and these changes has not been established.
Terbinafine clearance is increased 100% by rifampin, a CyP450 enzyme inducer, and decreased 33% by cimetidine, a CyP450 enzyme inhibitor. Terbinafine clearance is unaffected by cyclosporine.
There is no information available from adequate drug-drug interaction studies with the following classes of drugs: oral contraceptives, hormone replacement therapies, hypoglycemics, theophyllines, phenytoins, thiazide diuretics, beta blockers, and calcium channel blockers.
Lamasil Contraindications
LAMISIL (terbinafine hydrochloride tablets) Tablets are contraindicated in individuals with hypersensitivity to terbinafine or to any other ingredients of the formulation.
Additional information about Lamasil
Lamasil Indication: For the treatment of interdigital tinea infections.
Mechanism Of Action: Lamasil is hypothesized to act by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Terbinafine
Synonyms: Terbinafine hydrochloride; Ternbinafine HCl; Terbinafine HCl
Drug Category: Trypanocidal Agents; Antifungals; Allylamines
Drug Type: Small Molecule; Approved; Investigational
Other Brand Names containing Terbinafine: Bramazil; Lamasil; Lamisil; Lamisil AT; Terbina;
Absorption: Readily absorbed from gastrointestinal tract.
Toxicity (Overdose): Not Available
Protein Binding: >99%
Biotransformation: Hepatic
Half Life: 36 hours
Dosage Forms of Lamasil: Tablet Oral
Spray Topical
Cream Topical
Chemical IUPAC Name: N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
Chemical Formula: C21H25N
Terbinafine on Wikipedia: https://en.wikipedia.org/wiki/Terbinafine
Organisms Affected: Fungi
