Kayexalate

Kayexalate - General Information

Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, HIV. [Wikipedia]

Pharmacology of Kayexalate

Kayexalate affects the exchange of sodium and potassium in the body. Kayexalate is used to treat high levels of potassium in the blood, also called hyperkalemia. It is a potassium-binding ion-exchange resin that can be administered orally (25 grams in 20% sorbitol) or rectally (50 grams in 20% sorbitol).

Additional information about Kayexalate

Kayexalate Indication: Used to treat abnormally high potassium levels.
Mechanism Of Action: Kayexalate, which is not absorbed, binds excess potassium, carrying it out of the body.
Drug Interactions: Aluminium Risk of alkalosis in renal impairment
Bismuth Risk of alkalosis in renal impairment
Calcium Risk of alkalosis in renal impairment
Magnesium Risk of alkalosis in renal impairment
Triamterene Antagonism of action
Triamterene Antagonism of action
Spironolactone Risk of alkalosis in renal impairment
Potassium Risk of alkalosis in renal impairment
Eplerenone Risk of alkalosis in renal impairment
Amiloride Risk of alkalosis in renal impairment
Food Interactions: Not Available
Generic Name: Polystyrene sulfonate
Synonyms: SPS; Sodium polystyrene sulfonate; Polystyrene sulfonic acid; Sodium polystyrene sulfonic acid
Drug Category: Not Available
Drug Type: Small Molecule; Approved

Other Brand Names containing Polystyrene sulfonate: Kionex; Kayexalate;
Absorption: Not absorbed following oral administration.
Toxicity (Overdose): Overdose symptoms may include confusion, irritability, trouble thinking or concentrating, muscle weakness, or trouble breathing.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Kayexalate: Liquid Oral
Enema Rectal
Chemical IUPAC Name: calcium 2-ethenylbenzenesulfonate
Chemical Formula: C8H7CaO3S+
Polystyrene sulfonate on Wikipedia: https://en.wikipedia.org/wiki/Polystyrene_sulfonate
Organisms Affected: Humans and other mammals