Jilkon

Jilkon - General Information

A benzazepine derived from norbelladine. It is found in galanthus and other amaryllidaceae. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of gallamine triethiodide and tubocurarine and has been studied as a treatment for alzheimer disease and other central nervous system disorders. [PubChem]

 

Pharmacology of Jilkon

Jilkon is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Jilkon is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Jilkon is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, Jilkon's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that Jilkon alters the course of the underlying dementing process.

 

Jilkon for patients

Galantamine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Galantamine is in a class of medications called acetylcholinesterase inhibitors. It works by increasing the amount of a certain natural substance in the brain that is needed for memory and thought. Galantamine may improve the ability to think and remember or slow the loss of these abilities in people who have AD. However, galantamine will not cure AD or prevent the loss of mental abilities at some time in the future.

 

Jilkon Interactions

 

Jilkon Contraindications

REMINYL (galantamine hydrobromide) is contraindicated in patients with known hypersensitivity to galantamine hydrobromide or to any excipients used in the formulation.

 

Additional information about Jilkon

Jilkon Indication: For the treatment of mild to moderate dementia of the Alzheimer's type.
Mechanism Of Action: Jilkon's proposed mechanism of action involves the increase of the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase.
Drug Interactions: Acepromazine Possible antagonism of action
Aceprometazine Possible antagonism of action
Alverine Possible antagonism of action
Amantadine Possible antagonism of action
Amitriptyline Possible antagonism of action
Amoxapine Possible antagonism of action
Atropine Possible antagonism of action
Azatadine Possible antagonism of action
Belladona Possible antagonism of action
Benztropine Possible antagonism of action
Biperiden Possible antagonism of action
Brompheniramine Possible antagonism of action
Carbinoxamine Possible antagonism of action
Chlorpheniramine Possible antagonism of action
Chlorpromazine Possible antagonism of action
Chlorprothixene Possible antagonism of action
Cimetidine Possible antagonism of action
Clemastine Possible antagonism of action
Clidinium Possible antagonism of action
Clomipramine Possible antagonism of action
Clozapine Possible antagonism of action
Cyclizine Possible antagonism of action
Cyclobenzaprine Possible antagonism of action
Cyproheptadine Possible antagonism of action
Darifenacin Possible antagonism of action
Desipramine Possible antagonism of action
Dexbrompheniramine Possible antagonism of action
Dicyclomine Possible antagonism of action
Dimenhydrinate Possible antagonism of action
Diphenhydramine Possible antagonism of action
Diphenoxylate Possible antagonism of action
Diphenylpyraline Possible antagonism of action
Disopyramide Possible antagonism of action
Doxepin Possible antagonism of action
Doxylamine Possible antagonism of action
Ethopropazine Possible antagonism of action
Flavoxate Possible antagonism of action
Flupenthixol Possible antagonism of action
Glutethimide Possible antagonism of action
Glycopyrrolate Possible antagonism of action
Hydroxyzine Possible antagonism of action
Hyoscyamine Possible antagonism of action
Imipramine Possible antagonism of action
Isocarboxazid Possible antagonism of action
Isopropamide Possible antagonism of action
Ketoconazole Ketoconazole increases the effect and toxicity of galantamine
Loxapine Possible antagonism of action
Methotrimeprazine Possible antagonism of action
Maprotiline Possible antagonism of action
Meclizine Possible antagonism of action
Meperidine Possible antagonism of action
Mesoridazine Possible antagonism of action
Methdilazine Possible antagonism of action
Mirtazapine Possible antagonism of action
Methylscopolamine Possible antagonism of action
Moclobemide Possible antagonism of action
Molindone Possible antagonism of action
Nortriptyline Possible antagonism of action
Olanzapine Possible antagonism of action
Orphenadrine Possible antagonism of action
Oxybutynin Possible antagonism of action
Perphenazine Possible antagonism of action
Propericiazine Possible antagonism of action
Paroxetine Paroxetine increases the effect and toxicity of galantamine
Phenelzine Possible antagonism of action
Phenindamine Possible antagonism of action
Pimozide Possible antagonism of action
Pheniramine Possible antagonism of action
Pipotiazine Possible antagonism of action
Procainamide Possible antagonism of action
Prochlorperazine Possible antagonism of action
Procyclidine Possible antagonism of action
Promazine Possible antagonism of action
Promethazine Possible antagonism of action
Propantheline Possible antagonism of action
Protriptyline Possible antagonism of action
Quetiapine Possible antagonism of action
Quinidine Possible antagonism of action
Quinidine barbiturate Possible antagonism of action
Risperidone Possible antagonism of action
Scopolamine Possible antagonism of action
Sertraline Possible antagonism of action
Solifenacin Possible antagonism of action
Thioproperazine Possible antagonism of action
Thioridazine Possible antagonism of action
Thiothixene Possible antagonism of action
Tizanidine Possible antagonism of action
Tolterodine Possible antagonism of action
Tranylcypromine Possible antagonism of action
Trazodone Possible antagonism of action
Trifluoperazine Possible antagonism of action
Triflupromazine Possible antagonism of action
Trihexyphenidyl Possible antagonism of action
Trimeprazine Possible antagonism of action
Trimethobenzamide Possible antagonism of action
Trimipramine Possible antagonism of action
Tripelennamine Possible antagonism of action
Triprolidine Possible antagonism of action
Trospium Possible antagonism of action
Ziprasidone Possible antagonism of action
Zuclopenthixol Possible antagonism of action
Food Interactions: Take with food.
Generic Name: Galantamine
Synonyms: Galanthamine; Galanthamine hydrobromide; (-)-Galanthamine
Drug Category: Nootropic Agents; Parasympathomimetics
Drug Type: Small Molecule; Approved

Other Brand Names containing Galantamine: Galantamin; Jilkon; Lycoremin; Lycoremine; Reminyl;
Absorption: Not Available
Toxicity (Overdose): LD₅₀=75 mg/kg (rat)
Protein Binding: 18%
Biotransformation: Not Available
Half Life: 7 hours
Dosage Forms of Jilkon: Tablet Oral
Capsule, extended release Oral
Chemical IUPAC Name: (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
Chemical Formula: C17H21NO3
Galantamine on Wikipedia: https://en.wikipedia.org/wiki/Galantamine
Organisms Affected: Humans and other mammals