Isomytal

Isomytal - General Information

A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)

Pharmacology of Isomytal

Not Available

Additional information about Isomytal

Isomytal Indication: Not Available
Mechanism Of Action: Isomytal (like all barbiturates) works by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. This GABAA receptor binding decreases input resistance, depresses burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increases both the amplitude and decay time of inhibitory postsynaptic currents. In addition to this GABA-ergic effect, barbiturates also block the AMPA receptor, a subtype of glutamate receptor. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS. Isomytal also appears to bind neuronal nicotinic acetylcholine receptors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Amobarbital
Synonyms: Not Available
Drug Category: Not Available
Drug Type: Small Molecule; Illicit; Approved

Other Brand Names containing Amobarbital: Isomytal;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Isomytal: Not Available
Chemical IUPAC Name: 5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione
Chemical Formula: C11H18N2O3
Amobarbital on Wikipedia: https://en.wikipedia.org/wiki/Amobarbital
Organisms Affected: Not Available