Infed: Full Drug Profile

Infed - General Information

Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Infed is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible.

Pharmacology of Infed

Iron dextran is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. It is for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Iron is essential to the formation of hemoglobin and to the function and formation of other heme and nonheme compounds. Untreated depletion of iron stores leads to iron-deficient erythropoiesis and, in turn, to iron deficiency anemia.

Infed for patients

Patients should be advised of the potential adverse reactions associated with the use of INFeD.

Infed Interactions

Infed Contraindications

Hypersensitivity to the product. All anemi as not associated with iron deficiency.

Additional information about Infed

Infed Indication

For treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Also used to replenish body iron stores in Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) patients receiving or not receiving erythropoietin and in Hemodialysis Dependent (HDD-CKD) and Peritoneal Dialysis Dependent (PDD-CKD) - Chronic Kidney Disease patients receiving an erythropoietin.

Mechanism Of Action

After iron dextran is injected, the circulating iron dextran is removed from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. The iron is immediately bound to the available protein moieties to form hemosiderin or ferritin, the physiological forms of iron, or to a lesser extent to transferrin. This iron which is subject to physiological control replenishes hemoglobin and depleted iron stores.

Drug Interactions

Alendronate Formation of non-absorbable complexes

Generic Name

Iron Dextran

Synonyms

Dextran iron; Dexferrum

Drug Category

Iron Supplement; Anti-anemic Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Iron Dextran

Imferon; Infed; Proferdex;

Absorption

The major portion of intramuscular injections of iron dextran is absorbed within 72 hours; most of the remaining iron is absorbed over the ensuing 3 to 4 weeks.

Toxicity (Overdose)

LD₅₀ = 500 mg/kg (mouse, IV). Dosages of iron dextran in excess of the requirements for restoration of hemoglobin and replenishment of iron stores may lead to hemosiderosis. Cases of severe, sometimes fatal, allergic reactions (loss of consciousness, collapse, difficulty breathing, hives, swelling, or convulsions) and severe low blood pressure (hypotension) have been reported with the use of iron dextran.

Protein Binding

100% (after release from dextran)

Biotransformation

Dextran, a polyglucose, is either metabolized or excreted.

Half Life

5 hours (some indications that it can be as long as 10 hours)

Dosage Forms of Infed

Injection, solution Intravenous

Chemical IUPAC Name

Iron dextran

Chemical Formula

(FeO.OH.2H2O)478 (Dx.COOH)9

Organisms Affected

Humans and other mammals