Histalog

Histalog - General Information

A histamine H2 agonist used clinically to test gastric secretory function. [PubChem]

Pharmacology of Histalog

Histalog is a histamine H2 agonist used in a test for measuring maximal production of gastric acidity or anacidity. This measurement can be used to diagnose diseases such as Zollinger-Ellison syndrome, whereby the volume of gastric and basal secretions is measured following betazole administration (greater than 60% of the maximal acid secretion following betazole stimulation). In another test, gastritis can be diagnosed given late absence of gastric acid which is unresponsive to betazole stimulation. Histalog can be used as a gastric secretory stimulant instead of histamine with the advantage of not provoking side effects and thus not requiring the use of antihistaminic compounds.

Additional information about Histalog

Histalog Indication: For use clinically to test gastric secretory function.
Mechanism Of Action: Histalog is a histamine analogue. It produces the same effects as histamine, binding the H2 receptor which is a mediator of gastric acid secretion. This agonist action thereby results in an increase in the volume of gastric acid produced.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Betazole
Synonyms: Betazolo [DCIT]; Betazolum [Inn-Latin]; Betazol [Inn-Spanish]; Ametazole
Drug Category: Gastrointestinal Agents; Histamine Agonists; Diagnostic Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Betazole: Histalog;
Absorption: Rapid and complete.
Toxicity (Overdose): Not Available
Protein Binding: > 99%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Histalog: Not Available
Chemical IUPAC Name: 2-(2H-pyrazol-3-yl)ethanamine
Chemical Formula: C5H9N3
Betazole on Wikipedia: https://en.wikipedia.org/wiki/Betazole
Organisms Affected: Humans and other mammals