Hesperin
Hesperin - General Information
Hesperin belongs to the flavanone class of flavonoids. Hesperin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
Pharmacology of Hesperin
Hesperin is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. Hesperin may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotective and anticarcinogenic actions.
Additional information about Hesperin
Hesperin Indication: For lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again.
Mechanism Of Action: Hesperin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Hesperetin
Synonyms: Cyanidanon 4'-Methyl Ether 1626; Hesperitin; YSO2
Drug Category: Anticholesteremic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Hesperetin: Hesperin;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Hesperin: Not Available
Chemical IUPAC Name: (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
Chemical Formula: C16H14O6
Hesperetin on Wikipedia: https://en.wikipedia.org/wiki/Hesperetin
Organisms Affected: Humans and other mammals