Hesperin: Full Drug Profile
Hesperin - General Information
Hesperin belongs to the flavanone class of flavonoids. Hesperin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
Pharmacology of Hesperin
Hesperin is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. Hesperin may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotective and anticarcinogenic actions.
Additional information about Hesperin
Hesperin Indication: For lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again. Mechanism Of Action: Hesperin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Hesperetin Synonyms: Cyanidanon 4'-Methyl Ether 1626; Hesperitin; YSO2 Drug Category: Anticholesteremic Agents Drug Type: Small Molecule; Approved Other Brand Names containing Hesperetin: Hesperin; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Hesperin: Not Available Chemical IUPAC Name: (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Chemical Formula: C16H14O6 Hesperetin on Wikipedia: https://en.wikipedia.org/wiki/Hesperetin Organisms Affected: Humans and other mammals