Gerontine
Gerontine - General Information
A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Gerontine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. [PubChem]
Pharmacology of Gerontine
Gerontine is a polyamine. It is an organic molecule that is involved in cellular metabolism.
Additional information about Gerontine
Gerontine Indication: For nutritional supplementation, also for treating dietary shortage or imbalance
Mechanism Of Action: Gerontine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. Gerontine, is normally found in millimolar concentrations in the nucleus. Gerontine functions directly as a free radical scavenger, and forms a variety of adducts that prevent oxidative damage to DNA. Oxidative damage to DNA by reactive oxygen species is a continual problem that cells must guard against to survive. Hence, spermine is a major natural intracellular compound capable of protecting DNA from free radical attack. Gerontine is also implicated in the regulation of gene expression, the stabilization of chromatin, and the prevention of endonuclease-mediated DNA fragmentation.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Spermine
Synonyms: 1, 4-Bis(aminopropyl)butanediamine; 4,9-Diaza-1,12-dodecanediamine; 4,9-Diazadodecane-1,12-diamine; Spermin; Spermine dihydrate
Drug Category: Dietary supplement; Micronutrient
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing Spermine: Gerontine; Musculamine; Neuridine;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Gerontine: Not Available
Chemical IUPAC Name: N,N'-bis(3-aminopropyl)butane-1,4-diamine
Chemical Formula: C10H26N4
Spermine on Wikipedia: https://en.wikipedia.org/wiki/Spermine
Organisms Affected: Humans and other mammals
