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Genzyme: Full Drug Profile
Medically reviewed by Min Clinic Staff | Updated: January 2026
Genzyme - General Information
Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells.
Pharmacology of Genzyme
This immunosuppressive product, obtained by immunization of rabbits with human thymocytes, contains cytotoxic antibodies directed against antigens expressed on human T-lymphocytes. This reduces the host immune response against tissue transplants or organ allografts.
Additional information about Genzyme
- Genzyme) Indication
For prevention of renal transplant rejection
- Mechanism Of Action
- Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis.
- Generic Name
- Antithymocyte globulin
- Synonyms
- Thymoglobulin
- Drug Category
- Immunomodulatory Agents
- Drug Type
- Biotech; Approved
- Other Brand Names containing Antithymocyte globulin
- Genzyme); Thymoglobulin (SangStat Medical;
- Biotransformation
- Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production.
- Half Life
- 2-3 days
- Chemical IUPAC Name
- Rabbit anti-thymocyte globulin
- Organisms Affected
- Humans and other mammals