Genzyme

Genzyme - General Information

Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells.

Pharmacology of Genzyme

This immunosuppressive product, obtained by immunization of rabbits with human thymocytes, contains cytotoxic antibodies directed against antigens expressed on human T-lymphocytes. This reduces the host immune response against tissue transplants or organ allografts.

Additional information about Genzyme

Genzyme) Indication: For prevention of renal transplant rejection
Mechanism Of Action: Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Antithymocyte globulin
Synonyms: Thymoglobulin
Drug Category: Immunomodulatory Agents
Drug Type: Biotech; Approved

Other Brand Names containing Antithymocyte globulin: Genzyme); Thymoglobulin (SangStat Medical;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production.
Half Life: 2-3 days
Dosage Forms of Genzyme): Not Available
Chemical IUPAC Name: Rabbit anti-thymocyte globulin
Chemical Formula: Not Available
Antithymocyte globulin on Wikipedia: Not Available
Organisms Affected: Humans and other mammals