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Funduscein-25: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Funduscein-25 - General Information

A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)

 

Pharmacology of Funduscein-25

Not Available

 

Funduscein-25 for patients

Skin will attain a temporary yellowish discoloration. Urine attains a bright yellow color. Discoloration of the skin fades in 6 to 12 hours; urine fluorescence in 24 to 36 hours.

 

Funduscein-25 Interactions

 

Funduscein-25 Contraindications

Contraindicated in those persons who have shown hypersensitivity to any component of this preparation.

 

Additional information about Funduscein-25

Funduscein-25 Indication: For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature. Mechanism Of Action: Funduscein-25 sodium is used extensively as a diagnostic tool in the field of ophthalmology. Funduscein-25 is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from adjacent areas. It is applied topically in the form of a drop or it can be injected intravenously to produce a fluorescein angiogram. Topical fluorescein is a useful tool in the diagnosis of corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Funduscein-25 angiography is used to diagnose and categorize macular degeneration, diabetic retinopathy, inflammatory intraocular conditions, and intraocular tumors. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Fluorescein Synonyms: Not Available Drug Category: Contrast Media Drug Type: Small Molecule; Approved Other Brand Names containing Fluorescein: Acid Yellow 73; Eosin; Fluorescein Sodium salt; Fluorescein acid; Fluorescein disodium salt; Fluorescein disodium salt dihydrate; Fluorescein sodium; Fluorescein, Disodium Salt, Fluorescein, disodium salt; Fluorescite; Funduscein-25; Uranin; Uranine; Absorption: Rapidly distributed Toxicity (Overdose): Not Available Protein Binding: 85% Biotransformation: Not Available Half Life: Not Available Dosage Forms of Funduscein-25: Solution IntravenousLiquid IntravenousStrip TopicalStrip OphthalmicLiquid Ophthalmic Chemical IUPAC Name: 3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one Chemical Formula: C20H12O5 Fluorescein on Wikipedia: https://en.wikipedia.org/wiki/Fluorescein Organisms Affected: Humans and other mammals