Folicet
Folicet - General Information
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]
Pharmacology of Folicet
Folic acid, a water-soluble B-complex vitamin, is found in foods such as liver, kidneys, yeast, and leafy, green vegetables. Folic acid is used to diagnose folate deficiency and to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid.
Folicet for patients
Folicet Interactions
Medications that interfere with your body's ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohn's disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (�g, sometimes mcg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.
Folicet Contraindications
Additional information about Folicet
Folicet Indication: For treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood.
Mechanism Of Action: Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.
Drug Interactions: Ethotoin Folic acid decreases the levels of hydantoin
Fosphenytoin Folic acid decreases the levels of hydantoin
Mephenytoin Folic acid decreases the levels of hydantoin
Phenytoin Folic acid decreases the levels of hydantoin
Amobarbital Folic acid decreases the effect of anticonvulsant
Aprobarbital Folic acid decreases the effect of anticonvulsant
Butabarbital Folic acid decreases the effect of anticonvulsant
Butalbital Folic acid decreases the effect of anticonvulsant
Butethal Folic acid decreases the effect of anticonvulsant
Dihydroquinidine barbiturate Folic acid decreases the effect of anticonvulsant
Heptabarbital Folic acid decreases the effect of anticonvulsant
Hexobarbital Folic acid decreases the effect of anticonvulsant
Methohexital Folic acid decreases the effect of anticonvulsant
Methylphenobarbital Folic acid decreases the effect of anticonvulsant
Pentobarbital Folic acid decreases the effect of anticonvulsant
Phenobarbital Folic acid decreases the effect of anticonvulsant
Primidone Folic acid decreases the effect of anticonvulsant
Quinidine barbiturate Folic acid decreases the effect of anticonvulsant
Secobarbital Folic acid decreases the effect of anticonvulsant
Talbutal Folic acid decreases the effect of anticonvulsant
Food Interactions: Not Available
Generic Name: Folic Acid
Synonyms: Folate; PGA; Pteroyl-L-glutamic acid; Pteroyl-L-monoglutamic acid; Pteroylglutamic acid; Pteroylmonoglutamic acid; Vitamin M; Vitamin Be; Vitamin Bc; Vitamin B9
Drug Category: Dietary supplement; Micronutrient
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing Folic Acid: Acifolic; Apo-Folic; Cytofol; Dosfolat B activ; Folacid; Folacin; Folbal; Folcidin; Foldine; Folettes; Foliamin; Folicet; Folipac; Folsan; Folsaure; Folsav; Folvite; Folvron; Incafolic; Millafol;
Absorption: Not Available
Toxicity (Overdose): IPR-MUS LD50 85 mg/kg,IVN-GPG LD50 120 mg/kg, IVN-MUS LD50 239 mg/kg, IVN-RAT LD50 500 mg/kg, IVN-RBT LD50 410 mg/kg
Protein Binding: Very high to plasma protein
Biotransformation: Hepatic
Half Life: Not Available
Dosage Forms of Folicet: Liquid Intravenous
Tablet Oral
Capsule Oral
Chemical IUPAC Name: (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
Chemical Formula: C19H19N7O6
Folic Acid on Wikipedia: https://en.wikipedia.org/wiki/Folic_Acid
Organisms Affected: Humans and other mammals
