Floxapen

Floxapen - General Information

Antibiotic analog of cloxacillin. [PubChem]

Pharmacology of Floxapen

Floxapen is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Floxapen has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Floxapen results from the inhibition of cell wall synthesis and is mediated through flucloxacillin binding to penicillin binding proteins (PBPs). Floxapen is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Additional information about Floxapen

Floxapen Indication: Used to treat bacterial infection by susceptible microorganisms.
Mechanism Of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, flucloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that flucloxacillin interferes with an autolysin inhibitor.
Drug Interactions: Methotrexate The penicillin increases the effect and toxicity of methotrexate
Demeclocycline Possible antagonism of action
Doxycycline Possible antagonism of action
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Methacycline Possible antagonism of action
Minocycline Possible antagonism of action
Oxytetracycline Possible antagonism of action
Rolitetracycline Possible antagonism of action
Tetracycline Possible antagonism of action
Food Interactions: Take on an empty stomach.
Generic Name: Flucloxacillin
Synonyms: Flucloxacilina [Inn-Spanish]; Flucloxacillin Sodium; Flucloxacillin-Sodium; Flucloxacilline [Inn-French]; Flucloxacillinum [Inn-Latin]; Floxacillin
Drug Category: Anti-Bacterial Agents; Penicillins
Drug Type: Small Molecule; Approved

Other Brand Names containing Flucloxacillin: Floxapen; Fluclox; Sesamol;
Absorption: Bioavailability is 50–70% following oral administration.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Hepatic.
Half Life: 0.75–1 hour
Dosage Forms of Floxapen: Not Available
Chemical IUPAC Name: (2S,5R,6R)-6-[[3-(2-chloro-6-fluorophenyl)-5-methyl1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C19H17ClFN3O5S
Flucloxacillin on Wikipedia: https://en.wikipedia.org/wiki/Flucloxacillin
Organisms Affected: Enteric bacteria and other eubacteria