Ethiodol
Ethiodol - General Information
Ethiodol is used by injection as a radio-opaque contrast agent. It is composed of iodine combined with ethyl esters of fatty acids of poppyseed oil, primarily as ethyl monoiodostearate and ethyl diiodostearate. The precise structure is not known.
Pharmacology of Ethiodol
There has been little detailed investigation of the metabolic fate of ethiodized oil in either man or animals. However, the fate of ethiodized oil following Iymphangiography in dogs has been reported. Koehler et al. employed I131-tagged ethiodol for lymphangiography in dogs and analyses of individual organs at various time intervals were done. The investigators reported an average of only 25% of the injected medium was retained in the lymphatics at the end of three days. An average of 50% was recovered from the lungs. They found the remainder of injected activity was fairly uniformly distributed throughout the body. Urinary excretion in the form of inorganic iodine was revealed as the chief mode of iodine loss from the system.
Ethiodol for patients
Ethiodol Interactions
No Information Provided.
Ethiodol Contraindications
IN HYSTEROSALPINGOGRAPHY
Ethiodol is contraindicated in patients hypersensitive to it. Ethiodol should not be injected intrathecally or intravascularly, or used in bronchography. A history of sensitivity to iodine contraindicates the use of Ethiodol; iodine is split off from fatty compounds and becomes free iodine in the body. Hysterosalpingography is contraindicated in intrauterine pregnancy, acute pelvic inflammatory disease, marked cervical erosion, endocervicitis in the presence of intrauterine bleeding, in the immediate pre-or postmenstrual phase, or within 30 days of curettage or conization.
IN LYMPHOGRAPHY
Ethiodol is contraindicated in patients hypersensitive to it. Ethiodol should not be injected intrathecally or intravascularly or introduced into the bronchial tree. Patients with known sensitivity to iodine should not have lymphography performed. Iodine is split off from fatty compounds and becomes free iodine in the body. Lymphography is contraindicated in patients with a right to left cardiac shunt, in patients with advanced pulmonary disease, especially those with alveolar-capillary block, and in patients who have had radiotherapy to the lungs.
Additional information about Ethiodol
Ethiodol Indication: For use as a radio-opaque medium for hysterosalpingography and lymphography, and as an antineoplastic agent when part of the iodine is 131-I.
Mechanism Of Action: Ethiodol is selectively retained in tumor vessels for long periods, and is used for imaging organs such as liver, lung, stomach, and thyroid. Labeled with I-131 or other beta emitters (Y-90 or P-32), ethiodized oil can deliver a high internal radiation dose to certain tumors with minimal effect on healthy tissues.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Ethiodized oil
Synonyms: EOE 13
Drug Category: Antineoplastic Agents; Contrast Media
Drug Type: Small Molecule; Approved
Other Brand Names containing Ethiodized oil: Ethiodol;
Absorption: Not Available
Toxicity (Overdose): Intravenous LD50 in dog is 1580mg/kg. Symptoms of overdose include dyspnea and change in clotting factors.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Ethiodol: Injection, solution Intralymphatic
Chemical IUPAC Name: Not Available
Chemical Formula: C20H38O2I
Ethiodized oil on Wikipedia: https://en.wikipedia.org/wiki/Ethiodized_oil
Organisms Affected: Humans and other mammals