Ethane
Ethane - General Information
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. [PubChem]
Pharmacology of Ethane
Ethane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Ethane for patients
Isoflurane, as well as other general anesthetics, may cause a slight decrease in intellectual function for 2 or 3 days following anesthesia. As with other anesthetics, small changes in moods and symptoms may persist for up to 6 days after administration.
Ethane Interactions
Isoflurane potentiates the muscle relaxant effect of all muscle relaxants, most notably nondepolarizing muscle relaxants, and MAC (minimum alveolar concentration) is reduced by concomitant administration of N2O. See CLINICAL PHARMACOLOGY.
Ethane Contraindications
Known sensitivity to Isoflurane, USP or to other halogenated agents.
Known or suspected genetic susceptibility to malignant hyperthermia.
Additional information about Ethane
Ethane Indication: For induction and maintenance of general anesthesia.
Mechanism Of Action: Ethane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Ethane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Ethane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Isoflurane
Synonyms: Not Available
Drug Category: Anesthetics; General Anesthetics
Drug Type: Small Molecule; Approved
Other Brand Names containing Isoflurane: Aerrane; Ethane; Forane; Forene; Isoflurane [Usan-Ban-Inn-Jan]; Isofluranum [Inn-Latin];
Absorption: Not Available
Toxicity (Overdose): LC50=15300 ppm/3 hrs (inhalation by rat)
Protein Binding: Not Available
Biotransformation: Minimal
Half Life: Not Available
Dosage Forms of Ethane: Liquid Respiratory (inhalation)
Chemical IUPAC Name: 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
Chemical Formula: C3H2ClF5O
Isoflurane on Wikipedia: https://en.wikipedia.org/wiki/Isoflurane
Organisms Affected: Humans and other mammals
