Estracyt
Estracyt - General Information
A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties. [PubChem]
Pharmacology of Estracyt
Estracyt is an antineoplastic agent indicated in the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate. Estracyt is a combination of estradiol with nornitrogen mustard. The precise mechanism of action of estramustine is unknown. Unlike other alkylating agents, estramustine does not directly damage DNA.
Estracyt for patients
Estracyt Interactions
Milk, milk products, and calcium-rich foods or drugs may impair the absorption of EMCYT.
Estracyt Contraindications
EMCYT Capsules should not be used in patients with any of the following conditions:
- Known hypersensitivity to either estradiol or to nitrogen mustard.
- Active thrombophlebitis or thromboembolic disorders, except in those cases where the actual tumor mass is the cause of the thromboembolic phenomenon and the physician feels the benefits of therapy may outweigh the risks.
Additional information about Estracyt
Estracyt Indication: For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate
Mechanism Of Action: The precise mechanism of action of estramustine is unknown.
Drug Interactions: Clodronate Clodronate increases the levels of estramustine
Food Interactions: Take on an empty stomach.
Do not take with milk or milk products.
Generic Name: Estramustine
Synonyms: Estramustinum [Inn-Latin]; Estramustine Sodium Phosphate; Estramustina [Inn-Spanish]; Estramustin Sodium Phosphate
Drug Category: Antineoplastic Agents; Radiation-Protective Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Estramustine: Emcyt; Estracyt;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 20 hours
Dosage Forms of Estracyt: Capsule Oral
Chemical IUPAC Name: (17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) N,N-bis(2-chloroethyl)carbamate
Chemical Formula: C23H31Cl2NO3
Estramustine on Wikipedia: https://en.wikipedia.org/wiki/Estramustine
Organisms Affected: Humans and other mammals