Emadine
Emadine - General Information
Emadine is an antihistamine used in eye drops to treat allergic conjunctivitis. [Wikipedia]
Pharmacology of Emadine
Emadine is a relatively selective H1-receptor antagonist.
Emadine for patients
To prevent contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the bottle. Keep the bottle tightly closed when not in use. Do not use if the solution has become discolored.
Patients should be advised not to wear a contact lens if their eye is red. EMADINE should not be used to treat contact lens related irritation. The preservative in EMADINE, benzalkonium chloride, may be absorbed by soft contact lenses. Patients who wear soft contact lenses and whose eyes are not red, should be instructed to wait at least ten minutes after instilling EMADINE before they insert their contact lenses.
Emadine Interactions
No Information Provided.
Emadine Contraindications
EMADINE is contraindicated in persons with a known hypersensitivity to emedastine difumarate or any of its components.
Additional information about Emadine
Emadine Indication: For the temporary relief of the signs and symptoms of allergic conjunctivitis.
Mechanism Of Action: Emadine is a relatively selective, histamine H1 antagonist. In vitro examinations of emedastine's affinity for histamine receptors demonstrate relative selectivity for the H1 histamine receptor. In vivo studies have shown concentration-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva following topical ocular administration. Emadine appears to be devoid of effects on adrenergic, dopaminergic and serotonin receptors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Emedastine
Synonyms: Emedastina [INN-Spanish]; Emedastinum [INN-Latin]; Emedastine difumarate
Drug Category: Anti-Allergic Agents; Histamine H1 Antagonists
Drug Type: Small Molecule; Approved
Other Brand Names containing Emedastine: Emadine;
Absorption: Ophthalmic use of emedastine usually does not produce measurable plasma concentrations.
Toxicity (Overdose): Somnolence and malaise have been reported following daily oral administration.
Protein Binding: Not Available
Biotransformation: Two primary metabolites, 5-hydroxyemedastine and 6-hydroxyemedastine, are excreted in the urine as both free and conjugated forms. The 5'-oxoanalogs of 5-hydroxyemedastine and 6-hydroxy-emedastine and the N-oxide are also formed as minor metabolites.
Half Life: The elimination half-life of oral emedastine in plasma is 3-4 hours.
Dosage Forms of Emadine: Liquid Ophthalmic
Chemical IUPAC Name: 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole
Chemical Formula: C17H26N4O
Emedastine on Wikipedia: https://en.wikipedia.org/wiki/Emedastine
Organisms Affected: Humans and other mammals
