Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Emadine: Full Drug Profile

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Emadine - General Information

Emadine is an antihistamine used in eye drops to treat allergic conjunctivitis. [Wikipedia]

 

Pharmacology of Emadine

Emadine is a relatively selective H1-receptor antagonist.

 

Emadine for patients

To prevent contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the bottle. Keep the bottle tightly closed when not in use. Do not use if the solution has become discolored.
Patients should be advised not to wear a contact lens if their eye is red. EMADINE should not be used to treat contact lens related irritation. The preservative in EMADINE, benzalkonium chloride, may be absorbed by soft contact lenses. Patients who wear soft contact lenses and whose eyes are not red, should be instructed to wait at least ten minutes after instilling EMADINE before they insert their contact lenses.

 

Emadine Interactions

No Information Provided.

 

Emadine Contraindications

EMADINE is contraindicated in persons with a known hypersensitivity to emedastine difumarate or any of its components.

 

Additional information about Emadine

Emadine Indication

For the temporary relief of the signs and symptoms of allergic conjunctivitis.

Mechanism Of Action
Emadine is a relatively selective, histamine H1 antagonist. In vitro examinations of emedastine's affinity for histamine receptors demonstrate relative selectivity for the H1 histamine receptor. In vivo studies have shown concentration-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva following topical ocular administration. Emadine appears to be devoid of effects on adrenergic, dopaminergic and serotonin receptors.
Generic Name
Emedastine
Synonyms
Emedastina [INN-Spanish]; Emedastinum [INN-Latin]; Emedastine difumarate
Drug Category
Anti-Allergic Agents; Histamine H1 Antagonists
Drug Type
Small Molecule; Approved
Other Brand Names containing Emedastine
Emadine;
Absorption
Ophthalmic use of emedastine usually does not produce measurable plasma concentrations.
Toxicity (Overdose)
Somnolence and malaise have been reported following daily oral administration.
Biotransformation
Two primary metabolites, 5-hydroxyemedastine and 6-hydroxyemedastine, are excreted in the urine as both free and conjugated forms. The 5'-oxoanalogs of 5-hydroxyemedastine and 6-hydroxy-emedastine and the N-oxide are also formed as minor metabolites.
Half Life
The elimination half-life of oral emedastine in plasma is 3-4 hours.
Dosage Forms of Emadine
Liquid Ophthalmic
Chemical IUPAC Name
1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole
Chemical Formula
C17H26N4O
Organisms Affected
Humans and other mammals