Dosing and uses of Vitamin B5 (pantothenic acid)
Adult dosage forms and strengths
tablet
- 100mg
- 200mg
- 500mg
Recommended Daily Intake
Take with food if administered orally
Men & Women >14 years: 5 mg/day
Pregnant women: 6 mg/day
Lactating women: 7 mg/day
Dietary Supplement
5-10 mg PO qDay
Neurodegeneration (Orphan)
Penatothenate phosphate
Orphan designation for pantothenate kinase assoicated neurodegeneration (PKAN)
Sponsor
- Retrophin, Inc; 777 Third Avenue, 22nd Floor; New York, NY 10017
Pediatric dosage forms and strengths
tablet
- 100mg
- 200mg
- 500mg
Recommended Daily Intake
Take with food if administered orally
<6 months: 1.7 mg/day
6-12 months: 1.8 mg/day
1-3 years: 2 mg/day
3 - 8 years: 3 mg/day
8 -13 years: 4 mg/day
13-18 years: 5 mg/day
Vitamin B5 (pantothenic acid) adverse (side) effects
Frequency not defined
Diarrhea
Contact dermatitis
Warnings
Contraindications
Hypersensitivity
Pregnancy and lactation
Pregnancy category: Not studied
Lactation: Not studied
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Nutrition
Sources: milk, lean beef, eggs, cabbage, broccoli, legumes
Function: required for intermediary metabolism of carbohydrates, proteins, and lipids; precursor of coenzyme A which is required for acetylation (acyl-group activation) reactions in gluconeogenesis, in the release of energy from carbohydrates, the synthesis and degradation of fatty acids, and the synthesis of sterols and steroid hormones, porphyrins, acetylcholine, and other compounds; essential for normal epithelial function
Deficiency: (rare) abd pain, vomiting, insomnia
Toxicity: >10 g/day can cause diarrhea
Pharmacology of Vitamin B5 (pantothenic acid)
Mechanism of action
Plays a role in the synthesis and maintenance of coenzyme A
Pharmacokinetics
Absorbed in the intestine
Excretion: Urine
Metabolism: Hydrolyzed in the intestine to coenzyme A
