Dosing and uses of Vexol (rimexolone ophthalmic)
Adult dosage forms and strengths
ophthalmic solution
- 1%
Postoperative Inflammation
2 gtts in affected eye QID, start 24hr after surgery x 2 weeks
Anterior Uveitis
1-2 gtts in affected eye Qhr during waking hours x 1 week, 1 gtts q2hr during waking hours x 1week (2nd week), then taper
Other Indications & Uses
Ocular corticosteroid, antiinflammatory agent
Effective in iritis, keratitis, conjunctivitis, and many ocular inflammatory diseases; bacterial and viral infections require concomitant antibacterial and antiviral coverage, respectively
Pediatric dosage forms and strengths
Safety and efficacy not established
Vexol (rimexolone ophthalmic) adverse (side) effects
Frequency not defined
Glaucoma
Cataract
Potentiate super infection
Slow wound healing
Warnings
Contraindications
Hypersensitivity to any component of the formulation
Herpes simplex keratitis, herpes simplex keratitis dendritic, ocular fungal disease, ocular tuberculosis, ocular viral disease
Pregnancy and lactation
Pregnancy category: C
Lactation: ophthalmic corticosteroids have not been reported to cause problems in nursing babies
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Vexol (rimexolone ophthalmic)
Absorption: following topical instillation of corticosteroids into the conjunctival sac, is absorbed into the aqueous humor, & systemic absorption occurs
Mechanism of action
Synthetic nonfluorinated corticosteroid
