pramoxine vaginal (Vagisil Maximum Strength, Azo Itch Relief Maximum Strength Analgesic Wipes)
Classes: Anesthetics, Topical; Antipruritics/Non-corticosteroid Topical
Dosing and uses of Vagisil Maximum Strength (pramoxine vaginal)
Adult dosage forms and strengths
vaginal wipes
- 1%
Feminine Itching
Apply to affected area up to 3-4 times/day
Pediatric dosage forms and strengths
Safety and efficacy not established
Vagisil Maximum Strength (pramoxine vaginal) adverse (side) effects
Frequency not defined
Irritation
Pruritus
Warnings
Contraindications
Hypersensitivity
Pregnancy and lactation
Pregnancy category: C
Lactation: Unknown if excreted in breast milk
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Vagisil Maximum Strength (pramoxine vaginal)
Mechanism of action
Local anesthetic; stabilizes neuronal membranes and prevent generation/conduction of nerve impulses by reducing sodium permeability and increasing action potential threshold
Absorption
Onset: 2-5 min
