phenol oropharyngeal (Cepastat, Ulcerease, Chloraseptic, Chloraseptic Warming Sore Throat Spray)
Classes: Local Anesthetics, Dental
Dosing and uses of Cepastat, Ulcerease (phenol oropharyngeal)
Adult dosage forms and strengths
oral solution (mouthwash/gargle)
- 0.6% (Ulcerease)
oral solution (spray)
- 1.4% (Chloraseptic)
lozenge (oral)
- 14.5mg (Cepastat)
Sore Throat
Ulcerease: Gargle or swish for 15 seconds, then expectorate; may repeat q2h
Chloraseptic: 5 sprays onto throat or affected area; may repeat q2h
Cepastat: Use up to 2 lozenges q2h PRn
Antiseptic Topical
Apply sparse amount gently to affected area once or q8-12hr
Pediatric dosage forms and strengths
oral solution (mouthwash/gargle)
- 0.6% (Ulcerease)
oral solution (spray)
- 1.4% (Chloraseptic)
lozenge (oral)
- 14.5mg (Cepastat)
Sore Throat
Ulcerease
- <3 years: Not established
- >3 years: Administer as in adults
Chloraseptic
- <2 years: Not established
- 2-12 years: 3 sprays onto throat or affected areas; may repeat q2h
- >12 years: Administer as in adults
Cepastat
- <6 years: Not established
- 6-12 years: 1 lozenge q2h PRN; not to exceed 10 lozenges/24 hours
- >12 years: Administer as in adults
Cepastat, Ulcerease (phenol oropharyngeal) adverse (side) effects
Frequency Not Specified
Acute epiglotitis
Edema of the epiglotitis/larynx
Warnings
Contraindications
Documented hypersensitivity
Cautions
Overdose may cause agitation, confusion, slurred speech, and CNS depression
Do not use for sore >7 days if pain, redness, or irritation continues
Pregnancy and lactation
Pregnancy category: C
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Cepastat, Ulcerease (phenol oropharyngeal)
Mechanism of action
Disinfectant, antiseptic, and local anesthetic
Pharmacokinetics
Metabolism: Metabolized to phenylglucuronide and phnyl sulfate, small amounts oxidized to catechol and quinoL
Excretion: Via urine