Dosing and uses of Travatan (travoprost ophthalmic)
Adult dosage forms and strengths
ophthalmic solution
- 0.004%
Open-Angle Glaucoma
Instill 1 gtt in affected eye qDay
Pediatric dosage forms and strengths
Safety and efficacy not established
Travatan (travoprost ophthalmic) adverse (side) effects
>10%
Increased pigmentation of iris & periorbital tissue & increased pigmentation, thickening, elongation & growth of eyelashes (59%)
Ocular hyperemia (35-50%)
1-10%
Decreased visual acuity (5-10%)
Ocular discomfort (5-10%)
Foreign body sensation (5-10%)
Pain (5-10%)
Pruritus (5-10%)
Abnormal vision (1-4%)
Blepharitis (1-4%)
Blurred vision (1-4%)
Cataract (1-4%)
Conjunctivitis (1-4%)
Dry eye (1-4%)
Iris discoloration (1-4%)
Keratitis (1-4%)
Lid margin crusting (1-4%)
Photophobia (1-4%)
Subconjunctival hemorrhage (1-4%)
Tearing (1-4%)
Postmarketing Reports
Prostaglandin analogs reported to cause periorbital and lid changes including deepening of the eyelid sulcus
Warnings
Contraindications
Hypersensitivity
Pregnancy
Pregnancy and lactation
Pregnancy category: C
Lactation: distributed in milk in animals; caution if used in nursing women
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Travatan (travoprost ophthalmic)
Absorption: through the cornea
Peak Plasma Time: within 30 min
Metabolism: hydrolyzed by esterases in the cornea
Excretion: urinary; complete systemic elimination within 1 hr
Mechanism of action
Prostaglandin F2-alpha analog; incr outflow of aqueous humor
