tolnaftate (Tinactin, Aftate, Barielle Fungus Rx, Breezee Mist Antifungal Foot Powder, Lamisil AF Defense, Absorbine, Ting Antifungal): Dosing and Uses

Dosing and uses of Tinactin, Aftate (tolnaftate)

• Adult
• Pediatric

Adult dosage forms and strengths

aerosoL

• 1%

Superficial Fungal Infections

Apply to affected area BId

May treat for 2-3 weeks but 4-6 weeks of therapy may be needed if skin is hyperkeratotic

Other Indications & Uses

Indicated for Tinea pedis, cruris, corporis, and versicolor, however, may want to use selenium sulfide 2.5% or clotrimazole 1% for Tinea versicolor

Pediatric dosage forms and strengths

aerosoL

• 1%

Superficial Fungal Infections

Apply to affected area BId

May treat for 2-3 weeks but 4-6 weeks of therapy may be needed if skin is hyperkeratotic

Tinactin, Aftate (tolnaftate) adverse (side) effects

Frequency not defined

Sensitization

Mild irritation

Warnings

Contraindications

Hypersensitivity

Pregnancy and lactation

Pregnancy category: C

Lactation: safety in nursing infants unknown

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology of Tinactin, Aftate (tolnaftate)

Absorption: none

Metabolism: N/A

Excretion: N/A

Mechanism of action

Exact mode of action is not known, but the drug has been demonstrated to distort the hyphae and stunt mycelial growth in susceptible fungi