tolnaftate (Tinactin, Aftate, Barielle Fungus Rx, Breezee Mist Antifungal Foot Powder, Lamisil AF Defense, Absorbine, Ting Antifungal)
Classes: Antifungals, Topical
Dosing and uses of Tinactin, Aftate (tolnaftate)
Adult dosage forms and strengths
aerosoL
- 1%
Superficial Fungal Infections
Apply to affected area BId
May treat for 2-3 weeks but 4-6 weeks of therapy may be needed if skin is hyperkeratotic
Other Indications & Uses
Indicated for Tinea pedis, cruris, corporis, and versicolor, however, may want to use selenium sulfide 2.5% or clotrimazole 1% for Tinea versicolor
Pediatric dosage forms and strengths
aerosoL
- 1%
Superficial Fungal Infections
Apply to affected area BId
May treat for 2-3 weeks but 4-6 weeks of therapy may be needed if skin is hyperkeratotic
Tinactin, Aftate (tolnaftate) adverse (side) effects
Frequency not defined
Sensitization
Mild irritation
Warnings
Contraindications
Hypersensitivity
Pregnancy and lactation
Pregnancy category: C
Lactation: safety in nursing infants unknown
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Tinactin, Aftate (tolnaftate)
Absorption: none
Metabolism: N/A
Excretion: N/A
Mechanism of action
Exact mode of action is not known, but the drug has been demonstrated to distort the hyphae and stunt mycelial growth in susceptible fungi
