Dosing and uses of Tigan (trimethobenzamide)
Adult dosage forms and strengths
capsules
- 300mg
injectable solution
- 100mg/mL
Emesis
300 mg PO q6-8hr Or
200 mg IM q6-8hr
Renal Impairment
CrCl<70 mL/min: Consider a lower dose
Pediatric dosage forms and strengths
capsules
- 300mg
Emesis
20 mg/kg/day PO divided q6-8hr
Geriatric dosage forms and strengths
Consider lower initial dose
Emesis
300 mg PO q6-8hr Or
200 mg IM q6-8hr
Tigan (trimethobenzamide) adverse (side) effects
Frequency not defined
Dizziness
Parkinson-like symptoms
Sedation
Headache
Hypersensitivity reactions
Irritation at injection site
Warnings
Contraindications
Hypersensitivity to trimethobenzamide
Premature infants or neonates
Injection contraindicated in children
Do not use IV
Children with suspected Reye's syndrome
Cautions
Hypotension may occur after deep IM injection
Suppositories discontinued due to lack of effectiveness
Pregnancy and lactation
Pregnancy category: C
Lactation: unknown whether drug is distributed into breast milk; avoid
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Tigan (trimethobenzamide)
Mechanism of action
Unclear, the drug appears to directly affect medullary chemoreceptor trigger zone by inhibiting emetic stimuli to the vomiting center
Pharmacokinetics
Onset: 15-35 min (IM), 10-40 min (PO)
Duration: 2-3 hr (IM), 3-4 hr (PO)
Bioavailability: BA of oral dose equals 60-100% of IM dose
Half-life elimination: 7-9hr
Metabolism: Liver
Metabolites: N-desmethyl & N-oxide derivatives
Excretion: Urine (30-50%), feces via bile
