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tenofovir AF: Dosing and Uses

 

Classes: HIV, NRTIs

Medically reviewed by Min Clinic Staff | Updated: January 2026

Dosing and uses of Tenofovir AF

 

HIV Infection

New tenofovir salt pending FDA approvaL

 

Pharmacology of Tenofovir AF

Mechanism of action

Nucleotide reverse transcriptase inhibitor (NRTI): prodrug of tenofovir; compared with tenofovir disoproxil fumarate (tenofovir DF, Viread), tenofovir alafenamide (AF) is a more targeted form of tenofovir than that has demonstrated high antiviral efficacy at a dose that is 10 times lower than tenofovir DF, as well as an improved renal and bone safety profile; inhibits HIV-1 RT by competing with the natural substrate deoxyadenosine 5′-triphosphate and, after incorporation into DNA, by DNA chain termination