Dosing and uses of Tenofovir AF
HIV Infection
New tenofovir salt pending FDA approvaL
Pharmacology of Tenofovir AF
Mechanism of action
Nucleotide reverse transcriptase inhibitor (NRTI): prodrug of tenofovir; compared with tenofovir disoproxil fumarate (tenofovir DF, Viread), tenofovir alafenamide (AF) is a more targeted form of tenofovir than that has demonstrated high antiviral efficacy at a dose that is 10 times lower than tenofovir DF, as well as an improved renal and bone safety profile; inhibits HIV-1 RT by competing with the natural substrate deoxyadenosine 5′-triphosphate and, after incorporation into DNA, by DNA chain termination
