Dosing and uses of Tantum (benzydamine)
Adult dosage forms and strengths
oral rinse
- 0.15%
Radiation-Associated Mucositis
Gargle or rinse 15 mL in mouth (for 30 seconds, followed by expulsion from mouth) 3-4 times per day
Begin treatment 1 day prior to radiation therapy and continue daily during treatment
Acute Pharyngitis
Gargle or rinse 15 mL in mouth (for 30 seconds, followed by expulsion from mouth) q1.5-2hr
Administration
Do not swallow
Pediatric dosage forms and strengths
<6 years old: Safety & efficacy not established
Tantum (benzydamine) adverse (side) effects
1-10%
Burning /stinging sensation
Nausea/vomiting
Numbness
Frequency not defined
Cough
Drowsiness
Dry mouth
Headache
Pharyngeal irritation
Warnings
Contraindications
Hypersensitivity
Cautions
Renal impairment
Pregnancy and lactation
Pregnancy category: Not available. Safety has not been established in pregnant women.
Lactation: excretion in milk unknown; use with caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Tantum (benzydamine)
Absorption: through oral mucosa
Metabolism: unknown
Excretion: urine
Mechanism of action
Local anesthetic & anti-inflammatory
