pentazocine/naloxone (Talwin NX)
Classes: Analgesics, Opioid Combos; Analgesics, Opioid Partial Agonist
Dosing and uses of Talwin NX (pentazocine/naloxone)
Adult dosage forms and strengths
pentazocine/naloxone
tablet: Schedule IV
- 50mg/0.5mg
Moderate-to-Severe Pain
1 tablet PO q3-4hr, may increase to 2 tablets q3-4hr PRN; not to exceed 12 tablets/day
Renal Impairment
CrCl 10-50 mL/min: 75% regular adult dose
CrCl <10 mL/min: 50% regular adult dose
Hepatic Impairment
Use caution
Pediatric dosage forms and strengths
pentazocine/naloxone
tablet: Schedule IV
- 50mg/0.5mg
Moderate-to-Severe Pain
<12 years: Safety and efficacy not established
>12 years: As adults; tablet PO q3-4hr, may increase to 2 tablets q3-4hr PRN; not to exceed 12 tablets/day
Geriatric dosage forms and strengths
Use caution; monitor closely
Moderate-to-Severe Pain
1 tablet PO q3-4hr, may increase to 2 tablets q3-4hr PRN; not to exceed 12 tablets/day
Warnings
Black box warnings
Talwin Nx is intended for oral administration only. Severe vascular reactions have resulted from misuse by injection
Contraindications
Hypersensitivity
Do not inject dissolved tablets
If prescribed for long-term use, take precautions to avoid increases in dose by the patient
Pregnancy and lactation
Pregnancy category: C
Lactation: use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
