Dosing and uses of Sucraid (sacrosidase)
Adult dosage forms and strengths
oral concentrate
- 8500 International units/mL
Congenital Sucrase-Isomaltase Deficiency (CSID)
2 mL (17,000 units) PO per meal or snack
Administration
Take half of dose at beginning of meal & half at end of meaL
Dilute in 60-120 mL water or milk, do NOT use fruit juice
Administer cold or at room temp
Pediatric dosage forms and strengths
oral concentrate
- 8500 units/mL
Congenital Sucrase-Isomaltase Deficiency (CSID)
>5 Months Old
- <15 kg: 1 mL (8500 units) PO per meal or snack
- >15 kg: 2 mL (17,000 units) PO per meal or snack
Administration
Take half of dose at beginning of meal & half at end of meaL
Dilute in 60-120 mL water, milk or infant formula, do NOT use fruit juice
Administer cold or at room temp
Sucraid (sacrosidase) adverse (side) effects
1-10%
Abdominal pain
Constipation
Dehydration
Diarrhea
Headache
Insomnia
Nausea
Wheezing
Nervousnes
Vomiting
Warnings
Contraindications
Hypersensitivity to sacrosidase, yeast, yeast products, glycerol, or papain
Cautions
Sacrosidase does not provide isomaltase, dietary starch restriction may be necessary
Hypersensitivity reactions including bronchospasm reported; initial dose needs to be administered where adequate medical response is available to treat an acute reaction within a few minutes; identify patients at risk by performing a skin test
Not evaluated for acquired disaccharidase deficiency
Use caution in patients with diabetes; sacrosidase enables absorption of fructose and glucose
Product may contain papain
Pregnancy and lactation
Pregnancy category: C (not absorbed, unlikely to cause fetal harm)
Lactation: Not absorbed, most likely safe
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Sucraid (sacrosidase)
Mechanism of action
Sucrase replacement: Breaks down dietary sucrose to absorbable monosaccharides, which is necessary for their absorption into the gut
Pharmacokinetics
Metabolism: Broken down in GI tract to component peptides & amino acids which are then absorbed as nutrients