Dosing and uses of Sotradecol, Trombovar (sodium tetradecyl sulfate)
Adult dosage forms and strengths
injectable solution
- 1%
- 3%
Venous Varices
0.5-2 mL IV (preferably 1 mL); 1% solution for general use & 3% solution for larger varicosities
No more than 10 mL of 3% solution/week
Administration
Place injection sites 2.4-4.7 in [6-12 cm] apart
Do not use if solution has particulate matter or discoloration
SC varicose veins: use only 1% solution, most effective when administered as a froth prepared by vigorously shaking syringe
Pediatric dosage forms and strengths
N/A
Sotradecol, Trombovar (sodium tetradecyl sulfate) adverse (side) effects
Frequency not defined
Nausea
Vomiting
Deep vein thrombosis
Pulmonary embolism
Cough
Shortness of breath
Pruritus of face and extremities
Redness of conjunctiva
Reversible hyperpigmentation of injection site
Injection site ulcer, necrosis following extravasation
Immune hypersensitivity reaction
Anaphylaxis (death reported)
Warnings
Contraindications
Hypersensitivity
Pregnancy
Incompetency of collateral deep veins in the legs
Incompetency of the valves of the greater & lesser saphenous veins before ligation
Thrombophlebitis
Tuberculosis & hyperthyroidism
Acute infections, prolonged recumbency
Cardiac insufficiency, diabetes, arterial disease
Varicosities caused by pelvic neoplasia
Cautions
Determine deep venous potency by angiography, Perthes test or Doppler test before commencing sclerotherapy
First injection of 0.5 mL of 1% solution followed by a few hours' observation for any signs of allergic reactions is recommended before second injection
Extreme anaphylactic reaction may be treated with 0.25 mL of 1:1000 epinephrine IV & side effects controlled by antihistamines
Extravasation may cause severe necrosis
Intra-arterial injection may result in amputation of the limB
Pregnancy and lactation
Pregnancy category: N/A, do not use
Lactation: N/A
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Sotradecol, Trombovar (sodium tetradecyl sulfate)
Metabolism: N/A
Excretion: N/A
Mechanism of action
Sclerosing agent
Administration
IV Administration
Place inj sites 2.4-4.7 in [6-12 cm] apart
Do not use if solution has particulate matter or discoloration
