Dosing and uses of Solage (mequinol/tretinoin)
Adult dosage forms and strengths
mequinol/tretinoin
topical solution
- (2%/0.01%)
Dermatologic Conditions
Apply to affected area qHS or evening
Other Indications & Uses
Solar lentigines
Pediatric dosage forms and strengths
mequinol/tretinoin
topical solution
- (2%/0.01%)
Acne Vulgaris
<12 years old: Safety & efficacy not established
>12 years old: Apply to affected area qHS or evening
Solage (mequinol/tretinoin) adverse (side) effects
>10%
Erythema (49%)
Peeling of skin (14%)
Pruritus (12%)
1-10%
Skin hypopigmented (5%)
Sensation of burning of skin
Stinging of skin
Tingling of skin
Application site reaction
Crusting
<1%
Phototoxicity
Warnings
Contraindications
Hypersensitivity
Pregnancy, women of childbearing potentiaL
Children
Cautions
Pts with moderately or heavily pigmented skin
Works gradually
Do not use larger than recommended amounts
May exacerbate vitiligo
Minimize exposure to sunlight or sunlamps
Discontinue if sensitivity develops
Pregnancy and lactation
Pregnancy category: X
Lactation: use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Solage (mequinol/tretinoin)
Peak Plasma: Mequinol: 10 ng/mL
Metabolism: N/A
Excretion: urine & feces
Mechanism of action
Mequinol: depigmenting agent
Tretinoin: may repair skin damage due to UV radiation
