Dosing and uses of Semprana (dihydroergotamine inhaled)
Migraine Headache
Oral inhalation administration form pending FDA approval for treatment of acute migraine
Pharmacology of Semprana (dihydroergotamine inhaled)
Mechanism of action
Binds with high affinity to 5-HT-1D-α and 5-HT-1Dβ; also bind to serotonin 5-HT-1A, -2A, and -2C receptors, noradrenaline α2A, α2B, and alpha receptors, and dopamine D2L and D3 receptors
Therapeutic activity attributed to agonist effect at 5-HT-1D receptors, which includes vasoconstriction of intracranial blood vessels, or activation of 5-HT1D may inhibit proinflammatory neuropeptide release
