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selenium (Selepen)

 

Classes: Trace Elements/Metals

Dosing and uses of Selenomax, Selepen (selenium)

 

Adult dosage forms and strengths

tablet

  • 50mcg
  • 100mcg
  • 125mcg
  • 200mcg

tablet extended release

  • 200mcg

capsule

  • 200mcg

injectable solution

  • 40mcg/mL

 

RDa

Male or female: 55 mcg/day

Pregnancy: 60 mcg/day

Lactating: 70 mcg/day

 

Supplementation

100-200 mcg/day PO with meals (preferably); may take 50 mcg PO qDay or q6hr

 

Pediatric dosage forms and strengths

tablet

  • 50mcg
  • 100mcg
  • 125mcg
  • 200mcg

tablet extended release

  • 200mcg

capsule

  • 200mcg

injectable solution

  • 40mcg/mL

 

RDa

<6 months: 15 mcg/day

6-12 months: 20 mcg/day

1-3 years: 20 mcg/day

4-8 years: 30 mcg/day

8-13 years: 40 mcg/day

13-18 years: 55 mcg/day

 

Selenomax, Selepen (selenium) adverse (side) effects

Frequency not defined

Irritability

 

Warnings

Contraindications

Undiluted injection into peripheral vein

 

Pregnancy and lactation

Pregnancy category: C

Lactation: Excreted in breast milk; use caution

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Selenomax, Selepen (selenium)

Mechanism of action

Antioxidant; cofactor in glutathione peroxidase; protects cell components from oxidative damage

Present in selenoproteins as selenocysteine amino acid residue

 

Pharmacokinetics

Excretion: Urine, feces, lungs, skin