Dosing and uses of Scleromate (morrhuate sodium)
Adult dosage forms and strengths
injectable solution
- 50mg/mL
Obliteration of Varicose Veins
May use test dose of 0.25-1 mL of 5% solution
Small/medium Veins: 50-100 mg IV
Large Veins: 150-250 mg IV
May repeat q5-7Days
Pediatric dosage forms and strengths
N/A
Scleromate (morrhuate sodium) adverse (side) effects
Frequency not defined
Drowsiness
Headache
Burning or cramping sensations
Pulmonary embolism
Anaphylactic reactions
Injection site reactions
Warnings
Contraindications
Persistent deep vein occlusion
Valvular incompetence
Acute superficial thrombophlebitis; underlying arterial disease
Varicosities caused by abdominal & pelvic tumors
Uncontrolled DM, thyrotoxicosis, TB, neoplasms, asthma, sepsis, blood dyscrasias, acute respiratory or skin disease
Bedridden patients
Cautions
Delay in patients with acute local or systemic infections
Extensive therapy inadvisable in severely debilitated/senile patients
Extravasation may cause tissue necrosis
Pregnancy and lactation
Pregnancy category: N/A (no info)
Lactation: N/A
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Scleromate (morrhuate sodium)
Mechanism of action
Sclerosing agent, causes inflammation of vascular intimal layer and consequent thrombus formation
Administration
IV Administration
May use a test dose (0.25-1 mL) first to determine sensitivity
If solid matter present, warm ampule by immersing in hot water until clear
Because injection froths easily, a large bore needle should be used to fill syringe
Use smaller bore needle for injection
May give dose as single or multiple injections
Storage
Store at 15-30°C
Do not expose to air
Do not freeze
