Dosing and uses of Riopan, CoMagaldrox, Maalox (aluminum-hydroxide-magnesium-hydroxide)
Adult dosage forms and strengths
aluminum hydroxide/magnesium hydroxide
oral suspension
- (500mg/500mg)/5mL
oral liquid
- (200mg/200mg)/5mL
Gastric Hyperacidity, Heartburn
10-20 mL PO between meals & qHs
Pediatric dosage forms and strengths
aluminum hydroxide/magnesium hydroxide
oral suspension
- (500mg/500mg)/5mL
oral liquid
- (200mg/200mg)/5mL
Gastric Hyperacidity, Heartburn
< 12 years old: Safety & efficacy not established
> 12 years old: 10-20 mL PO between meals & qHs
Riopan, CoMagaldrox, Maalox (aluminum-hydroxide-magnesium-hydroxide) adverse (side) effects
>10%
Aluminum oxide
- Chalky taste
- Constipation
- Fecal impaction
- Stomach cramps
Frequency not defined
Aluminum oxide
- Nausea
- Vomiting
- Aluminum intoxication
- Hypophosphatemia
- Osteomalacia
Magnesium oxide
- Diarrhea
- Hypermagnesemia
Warnings
Contraindications
Hypersensitivity to any component
Cautions
Renal failure, Mg-restricted diet
May increase or decrease rate &/or degree of absorption of concomitantly administered oral drugs by changing GI transit time or by binding the drug
Pregnancy and lactation
Pregnancy category: C
Lactation: excretion in milk unknown; use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Riopan, CoMagaldrox, Maalox (aluminum-hydroxide-magnesium-hydroxide)
Mechanism of action
Neutralizes gastric acid, increases gastric pH
Duration
Fasting: 20-60 min
1 hr pc: up to 3 hr
Excretion
Aluminium oxide: absorbed Al ions are eliminated in the urine (0.1-0.5 mg of Al in aluminium-containing antacid is absorbed from standard daily doses of antacid), insoluble or poorly absorbed Al salts in the intestines are excreted in the feces
Magnesium oxide: absorbed Mg ions (up to 30%) are eliminated in urine, unabsorbed drug is excreted in feces
