Dosing and uses of Rimso 50 (dimethyl sulfoxide)
Adult dosage forms and strengths
intravesicular solution
- 50%
Interstitial Cystitis
Instill 50 mL intravesicularly into bladder and allow to remain for 15 minutes; repeat q2Weeks until symptom relief
After maximum symptomatic relief achieved, may decrease frequency
Administration
Sometimes given as 'bladder cocktail' with heparin, NaHCO3, analgesics and steroids
Monitor: Vision
Pediatric dosage forms and strengths
Safety & efficacy not established
Rimso 50 (dimethyl sulfoxide) adverse (side) effects
Frequency not defined
Garlic breath
Garlic taste
Chemical cystitis, transient
Abnormal body odor
Pain following administration of agent (Moderate to Severe)
Anaphylactoid reaction (rare)
Warnings
Contraindications
None listed by the manufacturer
Cautions
Urinary tract malignancy
Risks of: anaphylactic reactions; transient chemical cystitis
Potential risk of eye lens opacity
Not for IV or IM use; intravesicular use only
Use caution in patients with urinary tract malignancy (vasodilatory effects may be harmful)
Pregnancy and lactation
Pregnancy category: C
Lactation: Excretion in milk unknown; use with caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Rimso 50 (dimethyl sulfoxide)
Metabolism: oxidized to dimethylsulfone & reduced to dimethylsulfide
Excretion: feces, urine, breath, sweat
Mechanism of action
Analgesic & antiinflammatory; may inhibit free radical formation
Has anti-inflammatory, analgesic, mast cell inhibition, and muscle relaxing effects
Pharmacokinetics
Absorption: Well absorbed
Metabolism: Oxidation to dimethyL
Excretion: Urine, feces, skin, lungs
Distribution: Rapidly penetrates tissues
Metabolism: Oxidized to dimethylsulfone & reduced to dimethylsulfide
