Dosing and uses of Ragweed vaccine (modified ragweed tyrosine adsorbate)
Adult dosage forms and strengths
Not available in United States
Dosage forms and strengths
injectable solution
- 500
- 1400
- 4300
- 210 units/mL (set of four 0.5 mL syringes)
Preseasonal Immunotherapy (Allergic Rhinitis due to Ragweed)
0.5 mL SC qWeek x 4 weeks
Use numbered syringes in order (1, 2, 3, 4)
Administer before ragweed season (start administration in late June)
Pediatric dosage forms and strengths
Not available in United States
Dosage forms and strengths
injectable solution
- 500
- 1400
- 4300
- 210 unit/mL (set of four 0.5 mL syringes)
Preseasonal Immunotherapy (Allergic Rhinitis due to Ragweed)
>8 years old: Same as adult
<8 years old: Not recommended
Ragweed vaccine (modified ragweed tyrosine adsorbate) adverse (side) effects
Frequency not defined
Hypersensitivity S/s
Inj site reaction
Wheezing
Nasal congestion
Chest tightness
Warnings
Contraindications
History of severe anaphylactic reaction to ragweed vaccine
Cautions
May pre-medicate w/ antihistamine 1 hr before inj
Be aware for signs of anaphylaxis; observe pt. in office for 20-30 min. after inj
Do not administer during ragweed season (mid-August to end of Sept.)
Wait 24 hr after fever or acute asthma attack before administration
Pregnancy and lactation
Pregnancy category: N/A
Lactation: not known if excreted in breast milk
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Ragweed vaccine (modified ragweed tyrosine adsorbate)
Metabolism: N/A
Excretion: N/A
Mechanism of action
Extract of ragweed (Ambrosia elatior) pollen; increased IgG may interfere with immediate hypersensitivity reaction