Quercetin

Suggested dosing of Quercetin

400-500 mg PO TId

Prostatitis: 500 mg PO BId

Cancer: 420-1400 mg/sq.meter IV bolus qWeek

 

Suggested uses of Quercetin

Seasonal allergy; prevention of diabetic cataracts; viral infections; CVd

Adjunctive therapy in cancer

Chronic prostatitis, interstitial cystitis

 

Efficacy

Possibly effective in treatment of nonbacterial chronic prostatitis, interstitial cystitis

Other uses mainly derived from animal studies

 

Quercetin adverse (side) effects

Frequency not defined

PO: Headache

PO: Paresthesia

IV: Dyspnea

IV: N/V

IV: Nephrotoxicity (>945 mg/sq. meter)

 

Warnings

Contraindications

Sophretin, meletin

 

Pregnancy and lactation

Pregnancy category: N/A

Lactation: N/A

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Quercetin

Metabolism: N/A

Excretion: N/A

 

Mechanism of action

Flavonoid found in many foods; anti-inflammatory, antioxidant

Inhibits aldose reductase in lens