Suggested dosing of Prunus africana, pygeum africanum (pygeum)
BPH
75-200 mg/d PO standardized extract
Standardized extract contains 14% triterpenes, 0.5% n-docosanoL
Suggested uses of Prunus africana, pygeum africanum (pygeum)
BPH
Traditionally had been used for inflammation, kidney disease, urinary problems, malaria, stomachache, fever, difficult urination, fever, madness, prostate gland inflammation
Efficacy
Likely effective for BPH symptoms; possibly less effective than saw palmetto
Reduces the functional symptoms of BPH. Decreases nocturia by 19%, increases peak urine flow by 23%, and reduces residual urine volume by 24% in men with BPH
Prunus africana, pygeum africanum (pygeum) adverse (side) effects
Nausea, abd pain
Warnings
Contraindications
Hypersensitivity
Pregnancy and lactation
Pregnancy category: N/A
Lactation: N/A
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Prunus africana, pygeum africanum (pygeum)
Metabolism: N/A
Excretion: N/A
Mechanism of action
Ferulic acid reduce prostatic cholesterol levels
Phytosterols inhib. prostaglandin synth.
