Dosing and uses of Prudoxin, Xepin (doxepin cream)
Adult dosage forms and strengths
cream
- 5%
Pruritus
Apply to affected area QId
Administration
Allow at least 3-4 hour intervals
No more than 8 days chronic use
Other Indications & Uses
Associated with atopic dermatitis, lichen simplex chronicus
Pediatric dosage forms and strengths
Not recommended
Prudoxin, Xepin (doxepin cream) adverse (side) effects
>10%
Burning/stinging (23%)
Drowsiness (20%; esp if applied to >10% BSA)
1-10%
Dizziness
Dry mouth
Eczema exacerbated
Edema
Fatigue
Mental changes
Pruritus
Taste perversion
Warnings
Contraindications
Hypersensitivity
Narrow-angle glaucoma
Urinary retention
Side effects incr by MAO inhibitors; discontinue MAOIs 2 wk before doxepin
Cautions
Risk of drowsiness
Possibility of significant systemic absorption, resulting in anticholinergic effects
Allow at least 3-4 hr between applications
Pregnancy and lactation
Pregnancy category: B
Lactation: may pass into breast milk; do not nurse
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Prudoxin, Xepin (doxepin cream)
Absorption: may be significant
Metabolism: CYP2D6
Mechanism of action
Potent histamine H1- & H2-receptor antagonist activity
