prednisolone ophthalmic (Pred Forte, Pred Mild, Inflamase Mild, Omnipred, Econopred Plus, Inflamase Forte)
Classes: Corticosteroids, Ophthalmic
Dosing and uses of Pred Forte, Pred Mild (prednisolone ophthalmic)
Adult dosage forms and strengths
ophthalmic suspension
- 0.12%
- 1%
ophthalmic solution
- 0.11%
- 0.9%
- 1%
Ophthalmic Inflammatory Conditions
1-2 gtt of 1% solution BID-QID (may be more frequent during initial 24-48 hr)
Conjunctivitis
1-2 gtt of 1% solution BID-QID (may be more frequent during initial 24-48 hr)
See also combo with gentamicin
Other Indications & Uses
Ocular corticosteroid, antiinflammatory agent
Effective in iritis, keratitis, conjunctivitis, and many ocular inflammatory diseases; bacterial and viral infections require concomitant antibacterial and antiviral coverage, respectively
Pediatric dosage forms and strengths
ophthalmic suspension
- 0.12%
- 1%
ophthalmic solution
- 0.11%
- 0.9%
- 1%
Ophthalmic Inflammatory Conditions
1-2 gtt of 1% solution BID-QID (may be more frequent during initial 24-48 hr)
Conjunctivitis
1-2 gtt of 1% solution BID-QID (may be more frequent during initial 24-48 hr)
See also combo with gentamicin
Pred Forte, Pred Mild (prednisolone ophthalmic) adverse (side) effects
Frequency not defined
Increased IOp
Ocular hypertension
Conjunctival hyperemia
Conjuctivitis
Corneal ulcers
Delayed wound healing
Glaucoma
Keratitis
Loss of accommodation
Optic nerve damage
Mydriasis
Posterior subcapsular cataract formation
Ptosis
Secondary ocular infection
Hypercorticoidism (rare)
Warnings
Contraindications
Epithelial defect, glaucoma, herpes, vaccinia, varicella, and other viral diseases of cornea or conjunctiva, mycobacterial infection of eye, fungal diseases of ocular structures, hypersensitivity to any ingredients
Cautions
Ocular steroids must be used cautiously
Prednisolone acetate suspension 1% is one of most potent agents available; prednisolone phosphate soln slightly less effective
Pregnancy and lactation
Pregnancy category: C
Lactation: not known if distributed in milk
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Pred Forte, Pred Mild (prednisolone ophthalmic)
Mechanism of action
Inhibits edema, fibrin deposition, capillary dilation, and phagocytic response of acute inflammation; also inhibits capillary proliferation, collagen deposition, and scar formation
Pharmacokinetics
Absorption: Corneal penetration is good; absorbed into aqueous humor and some systemic absorption
Excretion: Urine
