Dosing and uses of Podophyllum resin
Adult dosage forms and strengths
Not available in Us
Condyloma Acuminata
Apply with cotton-tipped applicator (no more than 1-2 mL); wipe off after 1 hr
May repeat in 1 week; leave solution on 4-6 hr on subsequent applications
Other Information
Verruca Vulgaris, Molluscum Contagiosum: cover with adhesive tape after application
Preparation: protect adjacent normal skin with petrolatum
Other Indications & Uses
Verruca vulgaris, benign papillomas (e.g., granuloma inguinale)
Pediatric dosage forms and strengths
<18 years old: safety & efficacy not established
Podophyllum resin adverse (side) effects
Frequency not defined
LocaL
- Severe necrosis/scarring of the anogenital area
- Paraphimosis
- Pseudoepitheliomatous hyperplasia
Systemic
- Urticaria
- Fever
- Paresthesia
- Polyneuritis
- Paralytic ileus
- Pyrexia leukopenia
- Thrombocytopenia
- Coma
Warnings
Contraindications
Hypersensitivity
Avoid EtOH for several hrs after Tx
Do not use on mucosal tissue, moles, birthmarks, large/extensive genital warts
Avoid in pts with diabetes or circulatory problems
Cautions
Only to be applied by doctor
Limit application to small area of intact skin
Pregnancy and lactation
Pregnancy category: X; not recommended
Lactation: unknown; avoid during breastfeeding
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
