Suggested dosing of Phosphatidylserine
Alzheimer's Disease
100 mg PO TId
Senile Dementia & Cognitive/Memory Impairment
100 mg PO TId
ADHD in Children
200-300 mg PO qDay
Suggested uses of Phosphatidylserine
Depression, mental impairment in geriatric, ADHd
Efficacy
Human trials show benefit in memory impairment, dementia
May lose its effectiveness with extended use > 16 weeks
Insufficient information for depression
Phosphatidylserine adverse (side) effects
Frequency not defined
None reported
Warnings
Contraindications
N/A
Pregnancy and lactation
Pregnancy category: N/A
Lactation: N/A
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Phosphatidylserine
Metabolism: N/A
Excretion: N/A
Mechanism of action
Major phospholipid in neuronal membranes
May increase acetylcholine release
