Dosing and uses of Pamprin Cramp (acetaminophen/magnesium salicylate/pamabrom)
Adult dosage forms and strengths
acetaminophen/magnesium salicylate/pamabrom
caplet
- 250mg/250mg/25mg
Menstrual Symptoms
Indicated for relief of symptoms associated with menstrual periods including cramps, headaches, backaches, water-weight gain, bloating, muscular aches
2 caplets PO q4-6hr prn; not to exceed 8 caplets/24 hr
Pediatric dosage forms and strengths
acetaminophen/magnesium salicylate/pamabrom
caplet
- 250mg/250mg/25mg
Menstrual Symptoms
Indicated for relief of symptoms associated with menstrual periods including cramps, headaches, backaches, water-weight gain, bloating, muscular aches
<12 years: Safety and efficacy not established
≥12 years: 2 caplets PO q4-6hr prn; not to exceed 8 caplets/24 hr
Pamprin Cramp (acetaminophen/magnesium salicylate/pamabrom) adverse (side) effects
Frequency not defined
Angioedema
Laryngeal edema
Pruritic maculopapular rash
Urticaria
Anaphylactoid reaction
Agranulocytosis
Leukopenia
Neutropenia
Pancytopenia
Thrombocytopenia
Thrombocytopenic purpura
Hepatotoxicity
Tinnitus (high or chronic dose)
Dyspepsia
Heartburn
Nausea
Vomiting
Stomach pain
Warnings
Contraindications
Hypersensitivity/allergy to salicylates or other ingredients
Cautions
Contains aspirin; children and adolescents should not use for symptoms of viral infections (eg, chickenpox, influenza) due to risk for Reye syndrome
Hepatic impairment or consumption of 3 or more alcoholic beverages/day may increase risk for liver damage (associated with acetaminophen) or GI bleeding (associated with magnesium salicylate)
Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash
Do not take with other products that contain acetaminophen due to risk of additive toxicity/overdose
Avoid with active peptic ulcer disease
Avoid in severe renal impairment (ie, CrCl <10 mL/min)
Pregnancy and lactation
Pregnancy category: D; avoid aspiring (NSAIDs) during pregnancy, particularly in third trimester because of risk for premature closure of the ductus arteriosus
Lactation: excreted in breast milk
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Pamprin Cramp (acetaminophen/magnesium salicylate/pamabrom)
Mechanism of action
Acetaminophen: Acts on hypothalamus to produce antipyresis
Magnesium salicylate: Acts on hypothalamus to produce antipyresis; anti-inflammatory properties attributed to prostaglandin synthetase inhibition resulting in decreased formation of thromboxane A2
Pamabrom: Weak diuretic action
